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It is prudent to reduce doses in obese patients.

It stimulates insulin release when blood sugar is high, reduces glucagon secretion to prevent excessive glucose production and slows the rate at which food leaves the stomach, so you end up feeling full for longer and naturally eat less

Pros and Cons of Semaglutide, Ozempic, Wegovy, and other GLP-1 drugs
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Blockade of the GLP-1 receptor and subdiaphragmatic vagal transmission rescued the deficient locomotor phenotype in ABX-treated mice

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