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Additionally, patients often experience reduced appetite and may consume less food and fluid than previously, further contributing to harder stools and infrequent defecation

They are expensive because many are still sold as branded medicines and some are complex to manufacture

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Surg Obes Relat Dis 14(9):13681372 Brown AM, Yang J, Zhang X, Docimo S, Pryo AD, Spaniolas K (2022) Bariatric surgery lowers the risk of major cardiovascular events

Individuals with a Personal or Family History of Medullary Thyroid Carcinoma (MTC) One of the most critical precautions is avoiding semaglutide in people who have a personal or family history of medullary thyroid carcinoma (a rare type of thyroid cancer)