glp 1 serena Williams shares her journey using GLP-1 treatments to lose weight Serena Williams on Taking a

Stopping GLP-1 therapy typically results in reversal of therapeutic effects, including deterioration in blood glucose control and weight regain within weeks to months

Ozempic and Wegovy, both based on the active ingredient semaglutide, were primarily designed to improve blood sugar control in type 2 diabetes

In December 2025, the TRIUMPH-4 trial reported that retatrutide 12 mg achieved a remarkable 28.7% mean weight loss at 68 weeks in patients with obesity and knee osteoarthritis, with substantial pain relief as well ( [71] )

Available at: Mayo Clinic

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A 2023 analysis in the Journal of Clinical Endocrinology & Metabolism noted that GLP-1 agents can reduce stomach acid secretion and alter intestinal pH, both of which may influence absorption of various medications