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Metformin carries a boxed warning for a rare but serious condition called lactic acidosis, a buildup of lactic acid in the blood

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The number of treatments needed to treat dark thighs varies based on the size of the treated area, the procedure being utilized, and the skin-matching process

30 minutes to 2 hours at room temperature: Likely still usable, but some potency reduction is possible depending on the specific formulation and ambient conditions