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The odds of having each NASH histological component were significantly lower at the end of trial for patients who received semaglutide compared to placebo (e.g., in STEP 2 study for semaglutide 1.0 mg/week: 0.25 for steatosis and 0.52 for inflammation)

The rationale for microdosing reflects clinical observation that GLP-1 receptor agonism intensity correlates with gastrointestinal tolerability

Trial outcomes are useful, but they do not replace individualized care

I 2 0.1%, 3 studies [1820]), myocardial infarction (RR 0.54, 95% CI 0.064.84

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And its neuroprotective effect has become a research hotspot in recent years