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Increased activity of HP GLP-1R neurons followed by Ex-4 injection reduced food intake, possibly due to volume transmission from NTS PPG neurons [79]

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It will be difficult to engineer balanced agonism into a single small-molecule because the sequence hybridisation of the dual and triple peptide agonists has no obvious chemical analogue

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Barkoudah E, Skali H, Uno H, Solomon SD, Pfeffer MA

Polly says Piper started with weight loss treatment, but the company is transitioning to Polly to build a broader wellness ecosystem that includes healthy aging, menopause care, longevity, and hormonal support