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The rush of launches underscores the scale of the opportunity, even as the domestic market remains at an early stage

Ashok Kumar Das, MD, FAMS, FICP, PhD, FRCP (London), is the Dean (Academic) and Professor of Medicine at Mahatma Gandhi Medical College & Research Institute, Sri Balajee Vidyapeeth, Pondicherry

Genetic and Biomarker Context: Appetite Regulation Predispositions Genetic variations in GLP-1 receptor (GLP1R), GIP receptor (GIPR), and melanocortin-4 receptor (MC4R) genes influence individual appetite sensitivity and gastrointestinal motility response to GLP-1 agonists

Orforglipron's signaling profile has been characterized in the peer-reviewed publication in Science Translational Medicine in 2024, which reported that orforglipron demonstrates a Gs-biased signaling profile with relatively reduced beta-arrestin recruitment compared to peptide agonists

They influence whether a client qualifies for surgery, how quickly they recover, what long-term complications look like, and how damages are evaluated