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10 , e019240 (2021)

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Androgen replacement has been associated with reductions in pro-inflammatory cytokine production and modulation of immune cell activity [24,25,26], mechanisms that may indirectly influence skeletal muscle preservation

Drug Delivery Transl Res

RNAi was performed by feeding adult staged worms (P0) bacterial expressing double stranded RNAs (dsRNAs) corresponding to the gene of interest as previously described (Kamath et al., 2001

Before administration of concomitant treatment, subjects underwent a 0.6 mg weekly dose increase to reach the maximum dose of 1.8 mg/day