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Early CVOTs on GLP-1RAs, such as the LEADER, Harmony Outcomes, REWIND, and SUSTAIN-6 trials, focused on patients with T2DM and demonstrated the cardioprotective effects of these agents, including liraglutide, albiglutide, dulaglutide, and semaglutide.[811] The potential cardiovascular benefits of GLP-1RAs in patients without diabetes remain an active area of research

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10 Even more concerning than sucrose are the health effects of high-fructose corn syrup (HFCS), which is consumed to the tune of 39.5 pounds per person, each year
