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Waist circumference also dropped more on tirzepatide (-18.4 cm vs -13.0 cm)

Because these drugs suppress appetite, people often cut back on snacks, sugary drinks, and fatty foods

This led to higher levels of cyclin D1, a protein crucial for promoting cell proliferation, suggesting a potential pathway for GLP-1RAs to increase risk for PDAC in humans

These can be effective and are often used alongside other treatments

2.3 Data extraction and risk of bias assessment Two independent reviewers (IR and SK) extracted the following data using a pre-tested form: Author name, publication year, country of origin

Many patients also see benefits in related conditions and daytime energy levels