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Weightloss medications are prescriptiononly and are typically considered for adults with: BMI of 30 or higher, or BMI of 27 or higher combined with a weightrelated condition (such as diabetes, high blood pressure, high cholesterol or sleep apnea) Most weightloss drugs should be used alongside lifestyle modifications, not as a standalone strategy

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Drug Interaction Studies JANUMET Coadministration of multiple doses of sitagliptin (50 mg) and metformin HCl (1000 mg) given twice daily did not meaningfully alter the pharmacokinetics of either sitagliptin or metformin in patients with type 2 diabetes

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However, waking up with a scratchy, irritated, or sore throat might leave you feeling confused and wondering if your treatment is the cause