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However, post-marketing surveillance and patient reports suggest that some individuals taking semaglutide do experience leg cramps during treatment

Nutrition matters more than ever While GLP-1 drugs suppress appetite, they also create new nutritional challenges

T3 also increases hepatic gluconeogenesis by increasing activity of phosphoenolpyruvate carboxykinase (PEPCK), an enzyme that enhances gluconeogenesis [17,18]

More recently, innovative molecules like the dual glucose-dependent insulinotropic polypeptide and the glucagon-like peptide 1 (GLP1R-GIPR) receptors agonists, such as tirzepatide, have shown even greater efficacy, with weight loss up to 18% [21]

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The trials primary endpointNASH resolution without worsening fibrosiswas achieved in strikingly higher proportions of semaglutide-treated patients across all dosage groups