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is supported by operating grants from the CIHR, a Banting and Best Diabetes CentreNovo Nordisk Chair in Incretin Biology and a Sinai HealthNovo Nordisk Foundation Fund in Regulatory Peptides

Furthermore, with the increasing prominence of sarcopenic obesity, preserving lean mass in any weight loss strategy is important and this will be an area of increasing clinical and research interest

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Mechanisms of action of GLP-1, GIP and GCG receptors in human target organs

However, with few clinical trials, it requires consistent, long-term use to achieve and sustain results

Across major trials: Lean mass typically represents 2540% of total weight lost , meaning 6075% is fat loss . Imaging studies suggest tirzepatide may improve muscle quality , reducing fat infiltration within muscle tissueeven as total lean mass declines. A prospective 12-month semaglutide study demonstrated favorable body-composition changes with preserved or improved functional outcomes in some participants. In short: body composition improves , even when the scale shows lean-mass reduction. Muscle Changes by Weight-Loss Method How to Preserve Muscle on Semaglutide or Tirzepatide Protein targets for GLP-1 patients A clinically supported target for preserving lean mass during weight loss is: 1.21.6 g/kg/day ( 0.540.73 g/lb/day ) for most adults Higher intakes approximately 0.71.0 g per pound of body weight per day may be beneficial for individuals performing regular resistance training, particularly during calorie restriction, to better preserve or increase lean mass. Distributing protein across meals (often ~2540 g per meal ) supports muscle protein synthesis. Resistance training 23 per week Resistance training provides the mechanical signal required to retain muscle.