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Cardiovascular outcomes trials of Incretin-Based therapies

Mild to moderate nausea and appetite changes are expected during the first 12 weeks

doi: 10.1016/j.jdiacomp.2014.12.006

Receptor desensitization : Over time, GLP1 receptors may become less responsive to consistent drug exposure, reducing the appetite-suppressing effect

As always, any treatment decisions should be taken together with your doctor

Collectively, the current set of published evidence provides support for the hypothesized neuromodulatory potential of gastrointestinal hormones in altering reward responses
