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those beginning at 0.25 mg often report milder or delayed symptoms compared to those stepping up more quickly

Kelly, Ph.D., Lucy D

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subgroup analyses were not reweighted between the groups

In the Phase 2 retatrutide trial published in the New England Journal of Medicine (2023), participants at the highest dose (12 mg) achieved a mean body weight reduction of approximately 24.2% over 48 weeks
