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Signs tirzepatide is working may include: Reduced appetite Less snacking between meals Feeling full faster Fewer food cravings Better blood sugar control Smaller clothing sizes Improved energy levels Reduced waist circumference Better eating habits More stable hunger levels throughout the day These improvements often occur before major weight loss becomes visible

While a 4% weight loss is a strong start, it's generally not quite enough to be seen as clinically significant in terms of overall health benefits for people with type 2 diabetes

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A stoppage period shorter than four half-lives has questionable benefits

However, weight loss can fluctuate depending on factors such as initial weight, diet, level of physical activity, and other health conditions