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Some case series have documented actual muscle gains during tirzepatide weight loss , particularly in participants new to strength training

These typically occur during the initial weeks of treatment or during dose increases

Homeostatic model assessment (HOMA) 2-B provides a validated tool to assess beta-cell function

For weight loss specifically, Phase 2 trial data suggests retatrutide produces greater average weight loss (22-24%) compared to tirzepatide (18-22%) at maximum doses

As a GIP receptor agonist, tirzepatide enhances insulin secretion and may potentially improve insulin sensitivity while reducing glucagon secretion, though these mechanisms continue to be studied

Imaging was performed with a STELLARIS 5 Cryo laser scanning confocal microscope (Leica, Germany)