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This was a randomized, double-blind, placebo-controlled trial

Notably, despite the positive effects on renal outcomes, the study also reported an increased incidence of gastrointestinal side effects, including nausea, vomiting, and diarrhea, though these were not statistically significant [89]

One observational study conducted in the UK showed a 0.51% reduction in HbA1c and a 5.8-kg reduction in weight, with one in six patients discontinuing insulin after 26 weeks of exenatide-insulin combination therapy

Clinical Profile of Exenatide To understand subsequent innovations, its helpful to summarize exenatides clinical profile (as the first GLP-1 RA): Efficacy: In trials, twice-daily exenatide (10 g BID) typically reduced HbAc by approximately 0.8%1.0% more than placebo by 30 weeks ( [61] ) ( [101] )

Last November, however, the ones with their eyes on the drug were cardiologists