weight regain after tirzepatide Long-term minimal with for adults with obesity, prediabetes Rebound Weight Gain After Stopping
Description
The four-week intervals between dose adjustments align with the medication's pharmacokinetic profile, as steady-state concentrations are achieved after approximately four weeks of consistent dosing

When it occurs, it is likely related to weight loss and reduced caloric intake rather than a direct medication effect
Follow the standard 4-week escalation schedule
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Key Takeaways Weight loss plateaus on Semaglutide are a normal metabolic adaptation, typically occurring between 20 and 60 weeks of treatment
