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The project is supported by RF-2021 (RF-2021-12372399)

Currently, the accepted model of insulin secretion is that of a separate first and second-phase of insulin secretion due to the release of insulin from functionally distinct and regulatable pools [54]

In the phase II trial published in the New England Journal of Medicine (2023), retatrutide demonstrated substantial weight loss efficacy, with participants achieving up to approximately 24% mean body weight reduction at the highest doses over 48 weeks

The population who switched were made up of a higher percentage of people in the 45-64 age range, female, white, not Hispanic or Latino, those with overweight/obesity, T2D, and those who initiated treatment before 2021

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CGMP (Current Good Manufacturing Practice): Required for drug manufacturers and 503B facilities