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As alpha 7nAChRs are involved in cognition, histamine-blocking agents (including some PTDs) may represent both metabolic and cognitive risk factors
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals
Key Takeaway: While clinical trials do not list body aches as a primary side effect, the systemic changes caused by semaglutide can lead to indirect discomfort that feels like muscle or joint pain
The administrative and logistical hurdles that follow, such as dealing with insurance and supply issues, can be frustrating and overwhelming for many patients
However, animal as well as patient data are inconsistent and suffer from several confounders (63, 64)
The trade-off between greater efficacy and increased side effect burden is real
