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Blundell J, Finlayson G, Axelsen M, et al
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In early clinical studies, retatrutide has delivered unprecedented weight lossup to 24.2% of body weight in less than a yearwhile also improving blood pressure, cholesterol, and liver fat content
The body defends against weight loss through mechanisms that increase hunger, reduce energy expenditure, and enhance nutrient absorption efficiency
Recent preclinical evidence demonstrates that central GLP-1R activation can suppress systemic inflammation by inhibiting TLR-mediated TNF- release via neuronal GLP-1Rs
