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Alm disso, pessoas com histrico de pancreatite, distrbios da tireide, insuficincia renal grave e gestantes ou lactantes devem ter cautela e, em alguns casos, evitar o uso da semaglutida

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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)

Consider magnesium supplementation

Zhang et al., Front