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Collectively, these mechanisms explain how population-level genetic associations translate into molecular drivers of MASLD and its progression to T2DM ( Figure 4 )
All medications carry the same safety profile and side effect risks as their branded counterparts

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GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone produced in the intestines in response to food intake

Animal model studies have suggested that GLP-1RAs may cause pancreatitis and exocrine dysplasia, but in the large RCTs and a meta-analysis, GLP-1RAs did not increase the risk of pancreatitis or pancreatic cancer [82,83]
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