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Stabilize cardiac membranes (if ECG changes present: peaked T waves, widened QRS, sine wave) Calcium gluconate 10%: 10 mL IV over 25 min Onset: 13 min Duration: 3060 min Protects myocardium, does not lower potassium

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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators

Exceedingly short half-life (12 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question

It was originally created to help regulate blood sugar in people with type 2 diabetes

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