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But there are some considerations to keep in mind before turning to weight loss drugs such as Ozempic, Wegovy, Mounjaro and Zepbound

Policy decisions on the reimbursement of tirzepatide in individual countries should be based on health technology assessments integrating long-term efficacy and safety clinical data with country-specific cost-utility analyses comparing tirzepatide with other glucose-lowering medications used in clinical practice

The ability of GLP-1 RAs to passivate or stabilise plaque requires further evaluation in human studies but may be a novel and important mechanism by which this class confers a reduced risk of future and recurrent ischaemic events, including both MI and ischaemic stroke

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Risk of bias was rated low for the RCT in most domains [14]

Most DA is transported to synaptic vesicle storage pools by vesicular monoamine transporter 2 (VMAT2) on the synaptic vesicle membrane, with a very low cytoplasmic DA concentration (17)