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This could be considered for peptides with slightly shorter, but still prolonged, half-lives, or if a more tightly controlled, slightly higher average exposure is desired without going to daily dosing

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In the 72-week SURMOUNT-1 trial summarised in Mounjaros Australian product information, average weight change ranged from -16.0% to -22.5% depending on dose, versus -2.4% with placebo

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