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Some people taking tirzepatide report increased sensitivity to cold temperatures

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Use of glucagon-like peptide 1 agonists for weight loss compared with bupropion-naltrexone was associated with an increased risk for pancreatitis, gastroparesis and bowel obstruction but not biliary disease, researchers reported in JAMA

It is supplied in capsule form and is widely studied for its ability to stimulate the endogenous release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) without directly administering these hormones