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No cases meeting Hy's Law criteria (ALT/AST elevation greater than 3 times ULN combined with bilirubin elevation greater than 2 times ULN) have been reported

In the DURATION-8 trial, patients treated with exenatide ER plus dapagliflozin achieved nearly double the weight reduction observed with each monotherapy, with numerically larger effects in individuals with higher baseline BMI

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These CagriSema numbers put it in direct competition with retatrutide monotherapy

A meta-analysis reported a modest positive effect of vitamin D supplementation on muscle strength in elderly individuals with deficiency, but no effect on muscle mass, nor on muscle preservation during caloric restriction [57, 58]

ExpiFectamine Transfection Enhancers I and II (Gibco) were added 1822 h later