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This diversity underscores its clinical significance and highlights the complexity of the underlying mechanisms, which may involve multifactorial interactions such as inflammation, neuronal dysfunction, disruptions in the gut-brain axis, and metabolic disorders
Other GLP-1 RAs have also shown varying benefits in clinical trials and are summarized in Table 1
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They induce ROS overproduction and sustained activation of NF-B, initiating pro-inflammatory responses, exacerbating cell damage and further advancing inflammation [149,150,151]
To offset that risk, these drugs are prescribed along with high protein supplements, prompting companies to explore this space
however, many patients also experience weight loss while on this medication
