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News Release: Lilly's oral GLP-1, orforglipron, demonstrated statistically significant efficacy results and a safety profile consistent with injectable GLP-1 medicines in successful Phase 3 trial

Concerns about thyroid cancer risk and the potential for sarcopenia or bone fragility in older patients further underscore the need for long-term surveillance (Nunn et al., 2024)

Obesity can be such a costly problem for humans and possibly the insurers, Martin said

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These agents act on GLP-1Rs distributed in pancreatic, gastrointestinal, cardiovascular, hepatic, and neural tissues, mediating both peripheral and central effects