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By modulating downstream genes like ACSL1 and RSAD2, the drug prevents the lipid accumulation required for M2 macrophage survival

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Secondary Effects of GLP-1 Agonists: Acute GI Symptoms vs Chronic Gut Microbiome Dysbiosis Some secondary effects of GLP-1 RAs are symptomatic and relatively acute, such as gastrointestinal (GI) changes (constipation, diarrhea, nausea and vomiting), therefore mitigation strategies are well known