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Iwilfin, an orally available inhibitor of ornithine decarboxylase, was approved based on the results of a single-arm study of children with HRNB who were initially treated with standard regimens, including immunotherapy

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Epidemiological studies have also demonstrated that the use of metformin in individuals with type 2 diabetes is associated with a lower risk of PD [26]

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However, there is currently no direct evidence confirming the neuropsychiatric effects of GLP1RA in humans, and high-quality randomized controlled trials (RCTs) are still lacking