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Besides, GLP-1 can also be produced by neurons in CNS (20, 93)

Retatrutide adds glucagon receptor agonism to the GLP-1 and GIP targets already covered by tirzepatide, which is hypothesised to further stimulate hepatic fatty acid oxidation and lipid clearance

The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

However, it is associated with an increased risk of gastrointestinal side effects such as nausea, vomiting, and diarrhea, which often leads to treatment discontinuation

The 72-week study enrolled 3,127 non-diabetic patients with obesity or overweight with complications

oral formulation 2019), and tirzepatide (2022)the latter being a dual GIP/GLP-1 agonist ( Table 2 ) ( Table 2 Overview of GLP-1 receptor agonists (GLP-1RAs) approved by the EMA and/or FDA, with year of authorization and main therapeutic indications