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Alternative and non-mutually exclusive mechanisms may involve favorable effects on basal energy expenditure [57] or on the choice of less energy-rich foods consumed in free-living conditions [58], although these latter hypotheses remain to be validated in clinical studies

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Diabetes Care, 48 (9), 16071611

3 Considering lab work thyroid, blood sugar/insulin, and hormone markers can reveal contributing factors that diet and medication alone wont fix

However, observational studies have identified potential risk-amplifying effects in specific clinical contexts

There was also a trend towards a significant main effect of treatment (main effect of treatment: F( 1,47 ) = 3.095, p 2 = 0.062, p = 0.085), but no other significant main effects of interactions ( p 0.342)