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It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants

Typical daily dose: 5,000 mcg (5 mg) once daily for 20 consecutive days

GLP-1 protein, secreted by intestinal endocrine cells, promotes insulin secretion, regulates gastrointestinal motility, and inhibits the secretion of GCG protein

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Conversely, the ECL1 of GIPR adopts an unwound and relaxed loop conformation, likely due to the presence of three proline residues (P195, P197 and P199)

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