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Description
Satiation gradually rises during a meal event as hunger diminishes, peaking at meal termination

By week 12, cumulative weight loss of 56% of baseline body weight is common in clinical trials, though individual results vary

Once weekly subcutaneous injection

Acknowledgements and funding The authors work on gut-derived hormones and obesity-diabetes has been generously supported over many years by Diabetes UK, Invest Northern Ireland, the Irish Endocrine Society, Northern Ireland Department for the Economy, and Ulster University Strategic Funding

The GIP receptor activation appears to reduce nausea compared to pure GLP-1 agonists, which is why retatrutide shows a 28% nausea rate versus 44% for semaglutide despite being more potent

Fatigue Some patients experience fatigue, particularly during dose titration
