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This Review summarizes the available data about combination immunotherapies in T1DM, particularly addressing their clinical importance.

Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice

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Hypothyroidism slows metabolism and makes weight loss harder, but GLP-1 receptor agonists like semaglutide can still be effective when thyroid hormone is optimized

Why this matters: Earlier single-center data suggested a higher risk (HR ~ 4.3), but larger, more representative analyses now paint a more reassuring picture