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The general recommendation for a sample size to assess the safety of a weight-reduction drug is 3,000 subjects randomized to the investigational drug within the to-be258 recommended dosage range and no fewer than 1,500 subjects randomized to placebo for at least 1 year of treatment at the maintenance dosage Multiple #obesitytrials have successfully used flexible dosing regimens

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In participants with obesity and chronic kidney disease without diabetes, once-weekly administration of semaglutide 2.4mg led to a reduction in albuminuria, body weight and systolic blood pressure compared with placebo, with no changes to creatinine or cystatin-C estimated glomerular filtration rate or measured glomerular filtration rate during the 24-week follow-up period.

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