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Previous non-response to GLP-1s: If youve tried other GLP-1 medications without success, semaglutide response may also be limited

A notable 70.2% of SELECT participants were on beta-blockers, which can affect weight loss

Eating smaller portions, avoiding greasy or heavily flavored foods, and staying hydrated often help reduce nausea intensity during this adjustment window

Despite the effectiveness of anti-obesity drugs in inducing initial weight loss, weight regain following treatment discontinuation remains a major clinical challenge, undermining long-term outcomes [11]

HOMA2 (updated HOMA model which took account of variations in hepatic and peripheral glucose resistance), homeostatic Model Assessment for IR (HOMA-IR), the oral glucose insulin sensitivity index (OGSI), fasting Insulin (FINS), and fasting plasma glucose (FPG) based on fasting glucose and insulin levels 439,440,441,442,443 are widely utilized IR measurements in clinical research

Successful early dietary intervention avoids obesity in patients with Prader-Willi syndrome: a ten-year follow-up