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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Zhao X., et al
Gradual dose titration significantly reduced side effect severity

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Some researchers hypothesize that the increased energy expenditure from glucagon activation means less of the caloric deficit needs to come from dietary restriction, which may be less catabolic to muscle tissue

Changes are typically small, often a 25 microgram change
