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Other notable adverse effects include: Injection site reactions such as erythema, pruritus, or swelling Fatigue reported in approximately 5% to 6% of patients Hypoglycemia when used in combination with insulin or sulfonylureas Increased heart rate with modest elevations of 2 to 4 beats per minute (a class effect of incretin therapies with uncertain clinical significance) Serious but rare adverse effects include acute pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), acute kidney injury (typically secondary to dehydration from gastrointestinal symptoms), and hypersensitivity reactions

They discuss a case of pulmonary air embolism, RV failure, and cardiac arrest secondary to an ocular venous air embolism

They can recommend additional testing, like a clinical test or a confirmatory ultrasound, to provide clarity

Long-term safety, full phase 3 publication, regulatory review, and head-to-head comparative trials are still needed