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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that acts on the same receptor as the endogenous incretin hormone which works by selectively binding and activating the GLP-1 receptor to increase glucose-dependent insulin secretion, reducing appetite, and slows gastric emptying
GLP-1 Orforglipron a low-molecular-weight oral GLP-1 receptor agonist

GLP-1 receptor agonists like tirzepatide can trigger gallstone formation in some patients, especially during rapid weight loss