do not combine dpp-4 inhibitors with glp-1 receptor agonists guideline Development of a treatment selection algorithm for SGLT2 and inhibitor therapies in people type 2 diabetes: a retrospective cohort study Dipeptidyl peptidase 4 inhibitors in

Cell Metab (2012) 16:296309

This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)

In murine and human islets, GLP-1, via phospholipase C (PLC), leads to an activation of PKC, followed by membrane depolarization and stimulation of insulin secretion

These drugs mimic the gut hormone GLP-1, which is released soon after eating

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

Additionally, they may impact the brains satiety centers and alter food preferences, encouraging healthier eating patterns