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TRIUMPH-4, the first Phase 3 obesity readout (Dec 2025), reported about 28.7% mean weight loss at the top dose at 76 weeks the largest figure seen in any GLP-class trial so far

Can I stay on a lower maintenance dose of semaglutide instead of stopping completely

Steady consistent loss

Some unofficially call Alzheimers disease type 3 diabetes, for example, because issues with insulin signaling are tied to the accumulation of peptides characteristic of Alzheimers

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The analysis revealed that weight loss accounted for only 13% and 21% of the improvement in HOMA2-IR with tirzepatide (10 mg and 15 mg, respectively), indicating that weight loss was only partially responsible for the observed improvements in insulin resistance