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Berberine, a natural isoquinoline alkaloid, is increasingly recognized for its therapeutic effects on metabolic disorders, specifically its ability to regulate blood glucose and reduce body weight by influencing glucagon-like peptide-1 (GLP-1) levels (M

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Alongside the anticipated CV safety of many of these agents, evidence for certain sodiumglucose transporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have revealed potential cardioprotective effects in patients with T2D who are at high risk of CVD events