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Meal timing does not affect semaglutide's mechanism or effectiveness because it works by binding to GLP-1 receptors systemically, not locally in the digestive tract

Citation: Zhu Y, He Y, Yang H, Gao Y, Wang Y, Liu P, et al

Clinical trials show that fatigue is more common with Wegovy than with Ozempic or Rybelsus, but its possible to experience feelings of tiredness with any form of the medication

Dose reduction may work for select patients, but complete discontinuation remains difficult without alternative therapies or a multidisciplinary approach

This is likely due to the random effect model being selected for most NMA outcomes, while an ITC does not account for random effects between trials

They can provide guidance and appropriate treatment options to help you continue your medication safely