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There was no significant difference in plasma total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, leptin, adiponectin, resistin or interleukin-6 in Gipr Syn/ mice compared to Gipr fl/fl mice, although plasma tumour necrosis factor (TNF) and monocyte chemoattractant protein-1 (MCP-1) were lower in Gipr Syn/ mice than in Gipr fl/fl mice (Extended Data Fig

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On a measurement day, the mice performed 20 baseline trials without intervention, whereafter they received a semaglutide (1 mg/kg, Novo Nordisk, n = 16) or vehicle i.p