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These additions lack clinical data on their combined effects with tirzepatide, potential interactions, or efficacy

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A 2021 trial published in the New England Journal of Medicine (Lundgren et al.) found that combining exercise with GLP-1 treatment led to better long-term weight maintenance than either approach alone

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[DOI] [PubMed] [Google Scholar] 88.Zannad F, Ferreira JP, Pocock SJ, Anker SD, Butler J, Filippatos G, et al

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But before you evaluate any product in this space - supplement or pharmaceutical - you should actually understand what GLP-1 does in your body

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However, this creates a complex situation: while GLP-1 agonists might improve PCOS symptoms through weight loss, certain ones (like exenatide, lixisenatide, and tirzepatide) could potentially interfere with the oral contraceptives being used to manage the condition

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