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A meta-analysis of 21 clinical studies showed a weighted mean difference in body weight of 2.9 kg (95% confidence interval [CI] 3.6 to 2.2) with the maximum dose of each one of the GLP-1RAs [43]
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Among the Eli Lilly trials is one for orforglipron (LY3502970), a novel, oral non-peptide GLP-1 RA, which is the subject of four trials in the clinicaltrials.gov data
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